A New Drug Carrier System - Lipid Coated Chitosan-PLGA-Nanoparticles


Jens Schäfer1, Johannes Sitterberg1, M. N. V. Ravi Kumar2, and Udo Bakowsky1

1Department of Pharmaceutical Technology and Biopharmacy, University of Marburg, 35037 Marburg, Germany

2National Institute of Pharmaceutical Education & Research (NIPER), Mohali-160 062, India

e-mail: j.schaefer@staff.uni-marburg.de

URL: http://web.uni-marburg.de/iptb/institut/akbakowsky/JensSchaefer.html

 

Nanoscale drug delivery system for various application such as for pulmonary or nasal application are still a hope for successful future treatments. They can overcome problems like short biological half-life or biopharmaceutical difficulties. The controlled drug delivery offers multiple options for the optimisation of drug action by adjustments of the release rate, design of pro-drugs, and the alterations in the accumulation of the drugs at their desired site of action.
Using biodegradable polymers, different or pro-drugs, the kinetics of drug release can be controlled. Major drawbacks in application of PLGA particles include (i) their negative charge, and (ii) the poor transport characteristics of the PLGA nanoparticles through mucosal barriers. We reasoned that lipid coating might overcome the problems associated with PLGA particles and allow improved drug delivery to pulmunar and nasal mucosa. We developed a method to prepare cationic PLGA nanoparticles by an emulsion-diffusion-evaporation technique with chitosan-PVA as stabilizers. This includes the preparation of the colloidal carrier systems, the adsorptive or covalent surface modification of the carriers with various lipid mixtures and their characterization with physicochemical methods such as size and zetapotential. For the visualization of the nano-carriers, atomic force microscopy was used. The size, the surface charge and the viscoelastic properties of the Lipid-coated particles can be adjusted in a wide range.