From Self-Replicating Oligonucleotides to Self-Assembling DNA-Nanostructures

Günter von Kiedrowski

Ruhr-University, D-44780 Bochum, Germany


One of the future perspectives within chemical nanotechnology is to find methods for the low-cost mass fabrication of defined nanometer-sized objects for a given chemical function or a set of chemical functions. Living systems achieve this goal by self-replication and the underlying principle has been the subject for chemical mimicry for a number of years. On the other hand, self-assembly is nature´s key recipe for the synthesis of spatially and functionally defined nanoarchitectures and again, numerous examples from the field of supramolecular chemistry show that this recipe can be exploited in an artificial context. Thus, the quest for the low-cost mass fabrication of spatially and functionally defined nano-objects may also learn from the way how nature does it: Nanofabrication by means of the self-assembly of self-replicating modular units. In my lecture I would like to give a summary on chemical self-replicating systems, introduce our recent work on the informationally adressed self-assembly of DNA-based nanoobjects from trisoligonucleotidyls, and speculate about a possible way how to link self-replication and self-assembly to achieve the latter goal.


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